Garrett Out a Month; Reed, Sampson, Lane, Murray, Darnold Also Injured

The NFL landscape is being reshaped by a wave of significant player injuries following the opening week of the season. Los Angeles Rams defensive end Myles Garrett will undergo knee surgery and is expected to miss at least four weeks, a blow to the team's pass rush. Rams coach Sean McVay indicated that second-year player Josaiah Stewart will need to step up in Garrett's absence.

Elsewhere, Cleveland Browns running back Dylan Sampson is expected to miss significant time after injuring his knee in Sunday's loss to the Jaguars. Baltimore Ravens rookie wide receiver Ja'Kobi Lane is reportedly dealing with a fractured wrist, with MRI results pending. Arizona Cardinals quarterback Kyler Murray suffered a "very unique soft-tissue injury" that is considered short-term, though his Week 1 exit drew criticism for a hit by a Packers player. Seattle Seahawks quarterback Sam Darnold also sustained a "very unique soft-tissue injury" that is not expected to keep him sidelined for an extended period. The Detroit Lions have also added starting cornerback D.J. Reed to their Week 2 injury report, with three starting offensive linemen still limited or out.